Thursday, 30 June 2016

Testicular Cancer Guang Ming

睾丸癌偏愛年輕男性 早期動手術 預後良好

  • 泌尿外科顧問何志光醫生:如果非要切除雙側睾丸,那不意味著男性無法再生育,可以在手術前冷凍精子,保存生育的能力。
(八打靈再也訊)睾丸癌(testicularcancer)是指發生在睾丸的癌症,全球共有2%的男性被此癌盯上,而大馬的數據較低,根據2007年國家癌症登記局(NCR),國內只有0.9%的男性患上睾丸癌。泌尿外科顧問何志光醫生指出,雖然睾丸癌不是常見的男性癌症,但是它好發於15至40歲,這個年齡正值生命全盛期,如果病患羞於求醫或警覺性低,以致腫瘤轉移至另側睾丸或其他器官,那麼病患最終不僅要賠上雙側睾丸,還得面臨轉移癌的威脅。
何志光醫生解釋, 睾丸位於陰囊(scrotum)中,左右各一,具有製造男性荷爾蒙(如睾酮)及精子的功能。
他說,睾丸在完成一定的發育之後,由腹腔下降至陰囊,胎兒在出世時一般上已完成下降,使睾丸維持在比一般體溫低的狀況。
“不過,有些人的睾丸一直停留在腹腔中,無法下降,形成所謂的隱睾症(undescended testis),這造成睾丸無法`通風´,長期處於高溫的狀態,以致睾丸細胞發生變化,影響精子製造之餘,也徒增患癌風險。"
精子質量差 慎防睾丸癌
這也是為何美國紐約康奈爾醫學中心男性生殖醫學暨外科部主任馬克哥德斯登醫生曾披露,通過大量案例追蹤發現,精子質量有問題的人士,罹患睾丸癌的機率比一般人高出20倍。因此男性一旦發現自己的精子有問題,應考慮做睾丸癌篩查。
他提到,睾丸下降不全是一種很常見的小兒生殖系統先天性畸形疾病,但是有者仍能在1歲前自行下降,如果在1歲後仍無法下降,就要動手術把腹腔中的睾丸拉下來。
“父母也要特別留意新生兒有否隱睾症,因為對患兒而言,愈遲動手術,生育能力就愈容易受損,而且發生睾丸癌的機率明顯增高。"
他補充,除了隱睾症及精子質量低落,抽煙、具有睾丸癌家族史或曾患單側睾丸癌的男性,也要特別小心,因為這些都是誘發睾丸癌的病肇,“另外一個無法解釋的原因,就是睾丸癌患者以高佬居多。"
早期睾丸癌不痛
泌尿外科醫生何志光指出,早期睾丸癌腫並不會作痛,病患只會因為睾丸腫大而有所不適,僅15%患者會有疼痛感,有者會感到下腹、背部或腹股溝隱隱作痛或受壓。
他說,如果病患出現體重劇降、背部或(及)腹部疼痛、胸痛、咳嗽、呼吸困難、頭痛、腹部或(及)頸部的淋巴結腫大的症狀,那意味着病情已晉入晚期。
“如果腫瘤仍留在睾丸內,那為第一期睾丸癌。如果沒有積極治療,腫瘤可轉移至肺部,咳嗽為最具體的表現;腫瘤轉移至肝時,可形成黃疸;腫瘤轉移至腎臟時,可造成腎臟腫大。"
手術僅30分鐘
他提到,手術為睾丸癌的第一線治療,全名為根治性腹股溝睾丸切除術(radical inguinal orchiectomy),手術只需30分鐘,病患無需住院。
手術時,先在腹股溝(又稱鼠蹊部)位置開一個切口,經此途徑達陰囊上方,分離精索(由輸精管、動脈、靜脈血管等組成的條索狀組織),在腹股溝內環處先將精索及血管結扎切斷,然後再切除睾丸及腫瘤。
人工睾丸不普遍
進行睾丸腫瘤切除手術時,醫生可以將人工睾丸置入陰囊內,而這個假體的重量和感覺和正常睾丸相似,不知情的人是無法通過外觀辨識人造睾丸及自然睾丸。何志光醫生披露,在大馬,人工睾丸的置入並不普遍,這是因為此假體費用不菲,一個就需3000令吉(不包括手術費及住院費)。
“ 人工睾丸的材料為硅凝膠(silicone),經置入後不會與身體產生排斥現象,但是會有感染的風險。"
他分析,睾丸癌主要分為生殖細胞瘤(germ cell tumour)及非生殖細胞瘤(non-germ cell tumour),尤以前者最常見,佔了90%,“生殖細胞是睾丸里生產精子的細胞,而非生殖細胞與精子生產毫無關係。"
“ 生殖細胞瘤又分為精原細胞瘤(seminomas ) 及非精原細胞瘤(nonseminomas),前者病情發展較慢,而且對治療有反應,因此可使用放化療;後者來勢洶洶,癌細胞增長及轉移得非常快,但對放射線沒有反應,一般以化療應對。”
抽組織化驗 加速癌擴散
何志光醫生提醒,一般上,醫生不會在術前為睾丸癌病患抽取活體組織化驗,因為這會加速癌細胞的擴散,讓治療變得更艱難。
“這是因為當醫生抽取活體組織時,針管必須經過陰囊達到睾丸,完成抽取後,這支針管得從陰囊抽出,這時針管內的活體組織可能會沾染到陰囊,如果此活體組織是癌細胞,就會有癌細胞轉移之虞。"
他說,同樣地,如果經陰囊切除睾丸,癌細胞也是有可能跌進陰囊並造成擴散,這時就得連陰囊也一併切除,“原本只是初期的睾丸癌,經此一切,就進入了末期,多麼可惜啊!"
“比起其他癌症,睾丸癌的預後非常好,如果腫瘤沒有轉移,經治療後5年存活率達99%,即使出現轉移,若配合放化療,也能達到73%的5年存活率。"(光明日報/良醫:唐秀麗.2016.03.21)

Testicular Cancer

TESTICULAR CANCER

By  Thursday, May 5, 2016
Testicular Cancer
Written by: Dr. Christopher Ho Chee Kong

What is the testis?
Testis is an organ found only in males. It is responsible for producing sperm and the hormone called testosterone. Sperm is important to make babies while testosterone is responsible for making a man a man; giving him muscle bulk, facial, hoarse voice, virility, etc.
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Cancer Facts
In 2007, testicular cancer constitutes 0.9% of all cancers in Malaysian men (20th most common cancer). Majority are in the early stage (59.5%). [National Cancer Registry Report 2007, Ministry of Health Malaysia]. Unfortunately, lately we are seeing more coming in late with advanced stages of testicular cancer probably due to reluctance to see doctor or inadequate awareness.
Testicular cancer affects mainly those between 15-40 years old. This is the younger age group men who are at their peak and most productive phase of their life. To be hit by cancer at this prime age is usually a shock for most men and most of them will be in denial. A lot of men do not seek help to protect their ego and because of lack of awareness as this cancer is not common and not much publicity or knowledge has been given out.
Signs and Symptoms
Someone with testicular cancer usually does not have pain. Only 15% will complain of pain at the testis. Most of the time, the complaint will be abnormal enlargement of the testis or he feels a lump in the testis. Usually it affects only one side. There are other causes of enlargement or lump of the testis and this includes hernia (bowel or fat going into the scrotum), hydrocele (abnormal collection of fluids in the testis), or infection (Orchitis). When the cancer has spread elsewhere, it may cause other symptoms. If it has spread to the liver, he may have yellowish discolouration of the skin and eyes (jaundice), bone pain (if spread to the bones), cough with maybe blood in the phlegm (if it has spread to the lungs).
Causes
The real cause of testicular cancer is unknown. What happens is that the cells in the testis undergo changes and grow rapidly and abnormally. There are a few high risk factors for developing testicular cancer. This includes undescended testis, previous testicular cancer, someone else in the family having testicular cancer and smoking. There are other factors found to be associated with testicular cancer and this includes infertility and tall men. Masturbation, cycling is not a cause for testicular cancer.
In normal babies, the testis is formed in the abdomen and then descends down to the scrotum so that at birth, the testes are out in the scrotum. Being placed in the scrotum, outside the abdomen, puts it at a lower temperature than the body. This is important for healthy sperm production. In some cases, the testis does not go down to scrotum and gets stucked in the abdomen. This exposes the testis to high body temperature. The cells in the testis can then undergo transformation into abnormal cells which can turn cancerous in the long run.
testicular cancer 3.png

testicular cancer 4

testicular cancer 5.png

Diagnosis and Medical Scans
An ultrasound will be needed to confirm the suspicion of testicular cancer. Blood test called tumour markers will then be required. These are alpha fetoprotein (AFP), beta human chorionic gonadotropin (B-hCG) and lactase dehydrogenase (LDH). Not all types of testicular cancer will cause these tumour markers to be raised. The next step to confirm the cancer is not biopsy but removal of the testis. The reason why it is not biopsied is that biopsy may cause the cancer to spread to the scrotum (skin covering the testis) and make treatment more difficult. If necessary, CT scan will then be ordered to look for cancer spread and to stage the disease.
Treatment
The main treatment is removal of the testis called radical orchidectomy through an incision at the groin  region (inguinal). Whether or not further surgery to remove the lymph nodes, radiotherapy or chemotherapy is needed will depend on the type of testicular cancer and whether it has spread elsewhere. If the cancer is only in the testis and has not spread to other parts, surgery to remove the testis is adequate enough. Therefore, it is important to get it detected early. The surgery to remove the testis is simple and can be done in 30 minutes. It can be done as a day-care procedure (come in the morning and go back evening the same day) and most of the time, you can go back to normal activities in a week’s time.
If a man wants to preserve the shape of the scrotum and for psychological reasons, a testicular prosthesis can be inserted. It is silicone based.
Outcome
If the cancer has not spread, the chances for a 5 year survival rate is 99%. But if the cancer has spread, the chances for 5 year survival rate is 73%. Overall the outcome is a lot more promising compared to other types of cancers.
Prevention
As in all cancers, please avoid smoking. Also if a baby has undescended testis, it is advisable to get the testis pulled down into the scrotum through surgery (orchidopexy). Other than that, early detection is important. Therefore it is advised that men should check and examine their testis once a month in the shower. Feel for the surface. If there is any abnormality or enlargement, please see a doctor.
Famous sportsmen who had testicular cancer and survived
  • Lance Armstrong (cyclist)
In 1996 at the age of 25 he was diagnosed with late-stage testicular cancer which had already spread to his brain, lungs and abdomen. Was cure after treatment and went on to win 7 Tour de France cycling contest.

  • Jimmy White (snooker player)

  • Bobby Moore (English Footballer)
After surviving testicular cancer, won the World Cup at Wembley in 1966
testicular cancer 6
Dr. Christopher Ho Chee Kong,
MD, MS, MRCSEd, AM, MBU (Cert), FECSM, FICS, FRCSEd, FRCS (Urol) (Glasg) Consultant Urologist
Beacon International Specialist Hospital


CTA
Cancer does not discriminate. It can happen to anyone, anytime. Therefore early detection and treatment is essential and it can help save your life. So, get protected now from as low as RM1.50 a day.

College of Surgeons Malaysia

Office Bearers 2016 - 2017 



PresidentAssoc Prof Dr Hanafiah Harunarashid
Senior Vice PresidentProf Dr April Roslani
Hon SecretaryAssoc Prof Dr Lim Kean Ghee
Hon TreasurerProf Nur Aishah Taib
Council Members
Assoc Prof Dr Christopher Ho Chee Kong
Dr Siow Sze Li
Prof Dr Liew Ngoh Chin
Dr Ng Char Hong
Assoc Prof Datuk Dr Ismail Sagap
Assoc Prof Dr Ng Wuey Min
Dr Peter Wong Toh Lee
Prof Dr Chin Kin Fah